Tissue Extract from Brittle Star Undergoing Arm Regeneration Promotes Wound Healing in Rat

This study set out to evaluate the wound healing properties of brittle star extracts in vitro and vivo. Due great arm regeneration potential star, Ophiocoma cynthiae, present aimed effect hydroalcoholic undergoing models. The samples were collected from Nayband Bay, Bushehr, Iran. After induction stars, relating different times prepared. GC-MS analysis, MTT cell viability migration, Western blot, computational analysis tests performed. Based on findings, two BSEs chosen for vivo testing. Macroscopic, histopathological biochemical evaluations performed after treatments. results showed positive proliferative effects BSEs. Specifically, forty-two compounds detected all groups using their biological activities assessed. assay that 14 d BSE had a higher HFF cells than 7 BSE. migration area was significantly lower control group. blot demonstrated an increase expression proliferation-related proteins. Upon strong affinity some with proteins observed. evaluation changes percentage group better other groups. Histopathological scores In conclusion, extract O. cynthiae days promoted process rat skin model due migratory activity.